Hydrochloric Acid → 4-Fluorobenzimidic acid ethyl ester hydrochloride

HRID 617633Notes

Reaction equation

[F:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1.[ClH:10].[CH2:11]([OH:13])[CH3:12]>>[ClH:10].[F:1][C:2]1[CH:9]=[CH:8][C:5]([C:6](=[NH:7])[O:13][CH2:11][CH3:12])=[CH:4][CH:3]=1

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 702Ethanol

HCID 145174-Fluorobenzonitrile

Product 1

HCID 122821594-Fluorobenzimidic acid ethyl ester hydrochloride

Procedure

Ethyl 4-fluorobenzimidate hydrochloride was synthesized in the same manner as in Reference Example 2. That is, 4-fluorobenzonitrile (50.8 g, 0.407 mol) was treated with hydrogen chloride in ethanol (500 mL) to give 82.1 g (99%) of the target compound as colorless crystals.

Sources & evidence

ORD record: ord-96886884dc384d9bb54569d995d1b8b5
Source dataset: uspto-grants-1999_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05948785

Reaction notes

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