Hydrochloric Acid → Ethyl 4-methoxybenzimidate hydrochloride

HRID 617642Notes

Reaction equation

[C:1](#[N:10])[C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][CH:3]=1.[ClH:11].[CH2:12]([OH:14])[CH3:13]>>[ClH:11].[CH3:9][O:8][C:5]1[CH:6]=[CH:7][C:2]([C:1](=[NH:10])[O:14][CH2:12][CH3:13])=[CH:3][CH:4]=1

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 702Ethanol

HCID 701294-Methoxybenzonitrile

Product 1

HCID 12270046Ethyl 4-methoxybenzimidate hydrochloride

Procedure

Ethyl 4-methoxybenzimidate hydrochloride was synthesized in the same manner as in Reference Example 2. That is, anisonitrile (25.6 g, 0.199 mol) was treated with hydrogen chloride in ethanol (250 mL) to give 40.5 g (94%) of the target compound as pale-red crystals.

Sources & evidence

ORD record: ord-5314106d1e3e48fdb28b7926bf68f715
Source dataset: uspto-grants-1999_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05948785

Reaction notes

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