2-Pentanol → HCID 21848854, compound

HRID 617672Notes

Reaction equation

HRID 617672 reaction equation
S(Cl)(Cl)=O.[C:5]([O:8][C:9]1[CH:17]=[CH:16][C:12]([C:13]([OH:15])=[O:14])=[C:11]([F:18])[CH:10]=1)(=[O:7])[CH3:6].[CH3:19][CH:20](O)[CH2:21][CH2:22][CH3:23]>N1C=CC=CC=1>[C:5]([O:8][C:9]1[CH:17]=[CH:16][C:12]([C:13]([O:15][CH:20]([CH3:19])[CH2:21][CH2:22][CH3:23])=[O:14])=[C:11]([F:18])[CH:10]=1)(=[O:7])[CH3:6]

Participants

5

Reactant 3

HCID 223862-PentanolHCID 24386Thionyl ChlorideHCID 227214164-Acetoxy-2-fluorobenzoic acid

Product 1

HCID 21848854HCID 21848854, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Thionyl chloride in an amount of 60 ml was added to 10.8 g (0.06 mol) of 4-acetoxy-2-fluoro-benzoic acid, and the mixture was allowed to react under reflux for 7 hours. Then, excessive thionyl chloride was distilled off, and then 10 ml of pyridine and 3.5 g (0.0402 mol) of 2-pentanol were dropwise added.

Workup

  1. customto react
  2. temperatureunder reflux for 7 hours
  3. distillationThen, excessive thionyl chloride was distilled off

Sources & evidence

ORD record
ord-502012781f764cd1a70576ece2b656e0
Source dataset
uspto-grants-1999_09
Patent number
US05951914

Reaction notes

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