反应详情

温度

190 °C

2-Hydrazinopyridine (1.3 g, 11.8 mmol) and 7-methoxy-1,1-dimethyl-3,4-dihydro-1H-naphthalen-2-one (Compound A2, 2.4 g, 11.8 mmol) were dissolved in NMP (60 mL), and stirred at 190° C. for 48 hr. The reaction solution was diluted with ethyl acetate, washed with water and dried over magnesium sulfate. The drying agent was removed by filtration and the residues obtained after concentration under reduced pressure were purified by silica gel column chromatography (hexane/ethyl acetate) to obtain the target compound (white solid, 101 mg, 3%).

1. washwashed with water
2. dry with materialdried over magnesium sulfate
3. customThe drying agent was removed by filtration
4. customthe residues obtained
5. concentrationafter concentration under reduced pressure
6. customwere purified by silica gel column chromatography (hexane/ethyl acetate)
7. customto obtain the target compound (white solid, 101 mg, 3%)