Ammonia → 6-(2,4,6-Trimethyl-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine

HRID 617980Notes

Reaction equation

HRID 617980 reaction equation
[CH3:1][C:2]1[CH:10]=[C:9]([CH3:11])[CH:8]=[C:7]([CH3:12])[C:3]=1[CH2:4][C:5]#[N:6].[NH2:13][C:14]1[N:19]=[C:18]([NH2:20])[C:17]([CH:21]=O)=[CH:16][N:15]=1.N>C>[CH3:1][C:2]1[CH:10]=[C:9]([CH3:11])[CH:8]=[C:7]([CH3:12])[C:3]=1[C:4]1[C:5]([NH2:6])=[N:20][C:18]2[N:19]=[C:14]([NH2:13])[N:15]=[CH:16][C:17]=2[CH:21]=1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 3091762,4-Diaminopyrimidine-5-carbaldehydeHCID 5206982,4,6-Trimethylphenylacetonitrile

Product 1

HCID 218500226-(2,4,6-Trimethyl-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine

Reagents, catalysts & solvents 1

HCID 297MethaneSolvent

Procedure

The title compound was prepared according to Example 1, starting from 0.915 g of 2,4,6-trimethyl-benzyl cyanide and 0.76 g of 2,4-diamino-5-pyrimidine-carboxaldehyde; mp 276-282° C.; CIMS (1% ammonia in methane): m/z (relative intensity) 279 (MH+, 54), 280 (MH+ +1, 100)

Sources & evidence

ORD record
ord-ef24aac75e154f329edbecc3e5235834
Source dataset
uspto-grants-1999_09
Patent number
US05952342

Reaction notes

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