反应详情

A solution of diester 10-3 (19.0 g, 80.1 mmol), H2O (1.45 ml, 80.1 mmol), NaCl (10.5 g, 160.2 mmol) and DMF was heated to 170° C. for 18 h. The reaction was diluted with EtOAc and then washed with sat. NaHCO3, brine, dried (MgSO4) and concentrated. Flash chromatography (silica, 60% EtOAc/hexanes) afforded ester 10-4 as a brown oil.

1. washwashed with sat. NaHCO3, brine
2. dry with materialdried (MgSO4)
3. concentrationconcentrated