反应详情

2-(tert-Butyl-dimethyl-silyl)-5-(4-methyl-3-nitro-benzyl)-imidazole-1-sulfonic acid dimethylamide (2.32 g) was dissolved in 125 ml of ethyl acetate and 0.50 g of 10% palladium over charcoal (Pd/C) was added. The reaction mixture was hydrogenated on a Parr shaker at 44 lb/in2 for 14 hr. The catalyst was removed by filtration and the solvent was evaporated. The residue was purified by silica gel chromatography eluting with ethyl acetate:hexane (1:3), giving 1.05 g of 5-(3-amino-4-methyl-benzyl)-2-(tert-butyl-dimethyl-silyl)-imidazole-1-sulfonic acid dimethylamide as a white solid. ##STR111##

1. customThe catalyst was removed by filtration
2. customthe solvent was evaporated
3. customThe residue was purified by silica gel chromatography
4. washeluting with ethyl acetate:hexane (1:3)