反应详情

温度

60 °C

2.4 l of THF and 129.7 g (1.28 mol) of triethylamine are added, with stirring, to a suspension of 560 g (2.57 mol) of the compound from Example I in 4.8 l of water. The resulting solution is heated to 60° C., 155.4 g (1.28 mmol) of (S)-(-)-phenethylamine are added and the resulting suspension is stirred for 2 h at 60° C. The reaction mixture is cooled to 20° C., the precipitate is filtered off by suction, washed with 2.4 l of water/THF (2:1) and dried under reduced pressure.

1. temperatureThe reaction mixture is cooled to 20° C.
2. filtrationthe precipitate is filtered off by suction
3. washwashed with 2.4 l of water/THF (2:1)
4. customdried under reduced pressure