HCID 178450499, compound → HCID 21850846, compound

HRID 618446Notes

Reaction equation

HRID 618446 reaction equation
[C:1]([C:6](=[CH:12][NH:13][C:14]1[C:15]([O:20][CH3:21])=[N:16][CH:17]=[CH:18][CH:19]=1)[C:7]([O:9]CC)=O)(=[O:5])[CH2:2][CH2:3][CH3:4]>C1(OC2C=CC=CC=2)C=CC=CC=1>[C:1]([C:6]1[C:7](=[O:9])[C:19]2[C:14](=[C:15]([O:20][CH3:21])[N:16]=[CH:17][CH:18]=2)[NH:13][CH:12]=1)(=[O:5])[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 1

HCID 178450499HCID 178450499, compound2×

Product 1

HCID 21850846HCID 21850846, compoundYield 76%

Reagents, catalysts & solvents 1

HCID 7583Diphenyl EtherSolvent

Conditions

Temperature
50 °C

Procedure

11.23 g of ethyl 2-butyryl-3-(2-methoxypyridine-3-yl)aminoacrylate prepared in the above (A) was dissolved in 60 ml so diphenyl ether, and the resulting solution was heated to reflux for 2 hours and cooled to about 50° C. Petroleum ether (200 ml) was added to give precipitates, which were filtered to give 6.3 g (76%) of the titled compound as brown crystals.

Workup

  1. temperaturethe resulting solution was heated
  2. temperatureto reflux for 2 hours
  3. customto give
  4. customprecipitates
  5. filtrationwhich were filtered

Sources & evidence

ORD record
ord-8b34c204d63b4f9d81f1bb14ff2412f5
Source dataset
uspto-grants-1999_09
Patent number
US05952504

Reaction notes

Loading…