反应详情

By heating 11.3 g (40 mmol) of 6-benzyloxy-2,2-dimethylchroman-4-one with 3.1 g (44 mmol) of hydroxylamine hydrochloride in 27 ml of ethanol and 27 ml of pyridine for 3 h at 70° C., after distilling off the solvent in vacuo and precipitating with water, 12.5 g of product, m.p. 105-108° C., were obtained. The product was dissolved in EA, the solution was dried and concentrated, and the residue was crystallized using petroleum ether; m.p. 118-120° C.

1. distillationafter distilling off the solvent in vacuo
2. customprecipitating with water, 12.5 g of product, m.p. 105-108° C.
3. customwere obtained
4. customthe solution was dried
5. concentrationconcentrated
6. customthe residue was crystallized