反应详情

温度

45 °C

2-Iodo-pyridin-3-ol (50 mg, 0.226 mmol), K2CO3 (62 mg, 0.452 mmol) and DMF (2 ml) were added with para-methoxybenzyl chloride (46 μL, 0.339 mmol), and the mixture was stirred overnight at 45° C. The resultant was added with water, and then extracted with ethyl acetate. The organic layer was washed with saturated brine, and the resulting residues obtained after concentration under reduced pressure were purified by silica gel column (ethyl acetate/hexane) to obtain the title compound (21 mg, 27%).

1. extractionextracted with ethyl acetate
2. washThe organic layer was washed with saturated brine
3. customthe resulting residues obtained
4. concentrationafter concentration under reduced pressure
5. customwere purified by silica gel column (ethyl acetate/hexane)