Ammonium Hydroxide → HCID 141587647, compound

HRID 619023Notes

Reaction equation

HRID 619023 reaction equation
C1(O[C:8]([N:18]2[CH2:22][CH2:21][CH:20]([CH2:23][C:24]([N:26]3[CH2:31][CH2:30][CH:29]([CH:32]4[C:38]5=[N:39][CH:40]=[C:41]([Br:43])[CH:42]=[C:37]5[CH2:36][CH2:35][C:34]5[CH:44]=[C:45]([Cl:49])[CH:46]=[C:47]([Cl:48])[C:33]4=5)[CH2:28][CH2:27]3)=[O:25])[CH2:19]2)=[N:9][C:10](=[O:17])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)C=CC=CC=1.[NH4+:50].[OH-]>CC(O)C>[Br:43][C:41]1[CH:42]=[C:37]2[CH2:36][CH2:35][C:34]3[CH:44]=[C:45]([Cl:49])[CH:46]=[C:47]([Cl:48])[C:33]=3[CH:32]([CH:29]3[CH2:30][CH2:31][N:26]([C:24](=[O:25])[CH2:23][CH:20]4[CH2:21][CH2:22][N:18]([C:8](=[NH:50])[NH:9][C:10](=[O:17])[C:11]5[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=5)[CH2:19]4)[CH2:27][CH2:28]3)[C:38]2=[N:39][CH:40]=1

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 9832025HCID 9832025, compound

Product 1

HCID 141587647HCID 141587647, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Conditions

Temperature
25 °C

Procedure

The product of Example 28 is dissolved in 2-propanol and concentrated NH4OH is added. he mixture is stirred at 25° C. for 24 h and then evaporated to dryness. The residue is triturated with Et2O (2×250 ml) and the ether discarded. The resulting product is chromatographed on a silica gel column to give the title compound.

Workup

  1. customevaporated to dryness
  2. customThe residue is triturated with Et2O (2×250 ml)
  3. customThe resulting product is chromatographed on a silica gel column

Sources & evidence

ORD record
ord-413e1f63fadc40d281a3a40efd9f1bb3
Source dataset
uspto-grants-1999_09
Patent number
US05958890

Reaction notes

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