反应详情

To a suspension of 43.7 g (0.40 mol) of 2,6-diaminopyridine in 400 ml of ethanol was added 131.7 g (0.8 mol) of ethyl 2-chloroacetoacetate. The mixture was heated for 18 hours under reflux. After cooling, the resulting crystals was collected by filtration, washed with ethanol and ether successively to give 58.4 g of the desired compound (57.1%, pale yellow crystals).

1. temperatureThe mixture was heated for 18 hours
2. temperatureunder reflux
3. temperatureAfter cooling
4. filtrationthe resulting crystals was collected by filtration
5. washwashed with ethanol and ether successively