反应详情

To a suspension of 80 mg (2.0 mmol) of 60% sodium hydride (dispension in oil) in 10 ml of DMF was added, while stirring at room temperature, 338 mg (1.0 mmol) of 5-[2-[4-(amino)phenyl]ethan-1-ylamino]-3-ethoxycarbonyl-2-methylimidazo[1,2-a]pyridine. The mixture was stirred for 30 minutes. The reaction mixture was poured into water, extracted with ethyl acetate. The extract was washed with an aqueous saline solution, dried over anhydrous magnesium sulfate. The solvent was distilled off. The residue was purified by column chromatography (eluent: ethyl acetate) to give 151 mg of the desired compound (51.7%, pale brown solid).

1. additionwas added
2. stirringThe mixture was stirred for 30 minutes
3. extractionextracted with ethyl acetate
4. washThe extract was washed with an aqueous saline solution
5. dry with materialdried over anhydrous magnesium sulfate
6. distillationThe solvent was distilled off
7. customThe residue was purified by column chromatography (eluent: ethyl acetate)