Sodium Thiosulfate → HCID 21846967, compound

HRID 619738Notes

Reaction equation

HRID 619738 reaction equation
[CH:1]1[C:10]2[C:5](=[C:6]([S:11][C:12]3[C:13]([N+:22]([O-:24])=[O:23])=[CH:14][C:15]4[S:19][C:18](=[O:20])[NH:17][C:16]=4[CH:21]=3)[CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1.S([O-])([O-])(=[O:27])=S.[Na+].[Na+]>C(O)(=O)C>[CH:1]1[C:10]2[C:5](=[C:6]([S:11]([C:12]3[C:13]([N+:22]([O-:24])=[O:23])=[CH:14][C:15]4[S:19][C:18](=[O:20])[NH:17][C:16]=4[CH:21]=3)=[O:27])[CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1

Participants

4

Reactant 2

HCID 24477Sodium ThiosulfateHCID 21847000HCID 21847000, compound

Product 1

HCID 21846967HCID 21846967, compoundYield 61.6%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

5-(5-Isoquinolylsulfanyl)-6-nitro-2,3-dihydro-benzo[d][1,3]thiazol-2-one 300 mg (0.8 mmol) was dissolved in acetic acid 20 ml, 35% hydrogen peroxide 15 ml was added, and the mixture was stirred for 15 hours at room temperature. Saturated sodium thiosulfate was added to the reaction solution, the resulting precipitates were collected and washed with water, and 5-(5-isoquinolylsulfinyl)-6-nitro-2,3-dihydro-benzo[d][1,3]thiazol-2-one 190 mg (61.6%) was obtained.

Workup

  1. additionwas added
  2. customthe resulting precipitates
  3. customwere collected
  4. washwashed with water

Sources & evidence

ORD record
ord-249bdee3f38940feb4be61a6ec610947
Source dataset
uspto-grants-1999_09
Patent number
US05959107

Reaction notes

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