反应详情

Phosphorus oxychloride (315 g, 1.6 mole) was added dropwise over 4 hours to a stirred solution of 1-methoxynaphthalene (250 g) (2) in dried dimethylformamide (150 g). the reaction mixture was heated on a water bath for a further 4 hours, cooled, and poured onto ice (1 k) and 2M aqueous sodium acetate (1.5 l). The organic layer was extracted with dichloromethane (1 l) and washed with dilute hydrochloric acid and then with water. The organic layer was dried (MgSO4), filtered, and the solvent removed. 4-Methoxy-1-naphthaldehyde (3) was obtained as a pale yellow oil.

1. temperaturethe reaction mixture was heated on a water bath for a further 4 hours
2. temperaturecooled
3. extractionThe organic layer was extracted with dichloromethane (1 l)
4. washwashed with dilute hydrochloric acid
5. dry with materialThe organic layer was dried (MgSO4)
6. filtrationfiltered
7. customthe solvent removed