Sulfamide → HCID 21247719, compound

HRID 619990Notes

Reaction equation

HRID 619990 reaction equation
[CH2:1]([CH:6]1[CH2:11][O:10][CH:9]([C:12]2[CH:20]=[CH:19][C:15]([C:16](Cl)=O)=[CH:14][CH:13]=2)[CH2:8][CH2:7]1)[CH2:2][CH2:3][CH2:4][CH3:5].S(N)([NH2:24])(=O)=O>C1S(=O)(=O)CCC1>[C:16]([C:15]1[CH:19]=[CH:20][C:12]([CH:9]2[CH2:8][CH2:7][CH:6]([CH2:1][CH2:2][CH2:3][CH2:4][CH3:5])[CH2:11][O:10]2)=[CH:13][CH:14]=1)#[N:24]

Participants

4

Reactant 2

HCID 82267SulfamideHCID 21247967HCID 21247967, compound

Product 1

HCID 21247719HCID 21247719, compound

Reagents, catalysts & solvents 1

HCID 31347SulfolaneSolvent

Procedure

A solution of 29.5 g of p-(5-pentyl-2-tetrahydropyranyl)benzoyl chloride and 8 g of sulfamide in 500 ml of tetramethylene sulfone is heated at 120° for 4 hours, evaporated and worked up as usual. 2-p-cyanophenyl-5-pentyltetrahydropyran is obtained.

Workup

  1. customevaporated

Sources & evidence

ORD record
ord-5586723f6cf64843957c7580ea84c56b
Source dataset
uspto-grants-1989_04
Patent number
US04818431

Reaction notes

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