Acetone → HCID 14456454, compound

HRID 620032Notes

Reaction equation

HRID 620032 reaction equation
[CH2:1]([N:6]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[N:8]=[C:7]1[CH2:15][Cl:16])[CH2:2][CH:3]([CH3:5])[CH3:4].[NH2:17][C:18]1[CH:23]=[CH:22][N:21]=[CH:20][CH:19]=1.CC(C)=O>C(O)C>[ClH:16].[CH2:1]([N:6]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[N:8]=[C:7]1[CH2:15][NH:17][C:18]1[CH:23]=[CH:22][N:21]=[CH:20][CH:19]=1)[CH2:2][CH:3]([CH3:5])[CH3:4]

Participants

5

Reactant 3

HCID 180AcetoneHCID 17274-AminopyridineHCID 212484202-(Chloromethyl)-1-(3-methylbutyl)-1H-benzimidazole

Product 1

HCID 14456454HCID 14456454, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

1-isoamyl-2-chloromethylbenzimidazole (2.9 g, 12.2 mmol) prepared in the preceding step (b), 4-aminopyridine (3.9 g, 22.5 mmol) and ethanol (24 ml) were refluxed. After concentration of the reaction mixture in vacuo, the product was crystallized from acetone (2.9 g, 9.0 mmol) and recrystallized from ethanol, than the objective compound (1.5 g, 4.5 mmol) was obtained.

Workup

  1. temperaturewere refluxed
  2. customwas obtained

Sources & evidence

ORD record
ord-4d73f9bb3e9647cb8ecb336b948bbae7
Source dataset
uspto-grants-1989_04
Patent number
US04818761

Reaction notes

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