N-(2,3-Epoxypropyl)phthalimide → HCID 13365967, compound

HRID 620047Notes

Reaction equation

HRID 620047 reaction equation
[O:1]1[CH2:15][CH:2]1[CH2:3][N:4]1[C:12](=[O:13])[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]1=[O:14].[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]2[CH:24]=[N:25][C:26]([N:29]3[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]3)=[N:27][CH:28]=2)=[CH:19][CH:18]=1>C(O)(C)C>[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]2[CH:24]=[N:25][C:26]([N:29]3[CH2:34][CH2:33][N:32]([CH2:15][CH:2]([OH:1])[CH2:3][N:4]4[C:12](=[O:13])[C:11]5[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=5)[C:5]4=[O:14])[CH2:31][CH2:30]3)=[N:27][CH:28]=2)=[CH:19][CH:18]=1

Participants

4

Reactant 2

HCID 21601N-(2,3-Epoxypropyl)phthalimideHCID 4061276HCID 4061276, compound

Product 1

HCID 13365967HCID 13365967, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

0.022 of 2-(2,3-epoxypropyl)isoindole-1,3(2H)dione, 0.02 mol of 1-(5-(4-chlorophenyl)-2-pyrimidinyl)piperazine and 70 ml of isopropanol are heated to boiling for 2 hours. The mixture is evaporated and the residue is purified by column chromatography on silica gel 60. After elution with methylene chloride/alcohol (96:4), the compound is stirred with alcohol and filtered off with suction.

Workup

  1. customThe mixture is evaporated
  2. customthe residue is purified by column chromatography on silica gel 60
  3. washAfter elution with methylene chloride/alcohol (96:4)
  4. filtrationfiltered off with suction

Sources & evidence

ORD record
ord-99dc82009fe34c8f87c89afb08692915
Source dataset
uspto-grants-1989_04
Patent number
US04818756

Reaction notes

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