反应详情

A mixture of 4-fluorophenylacetic acid (123.0 g), 2-propanol (96.0 g), p-toluenesulphonic acid (9.6 g) and benzene (1.3 l) is refluxed for 7 hours with a Dean-Stark separator. The solution is washed with a 10% aqueous solution of sodium carbonate (2×500 ml) and with water (2×500 ml). After drying over magnesium sulphate, the solvent and the excess 2-propanol are evaporated in vacuo. The residue is distilled (51°-53°/3·10-2Torr) to yield isopropyl 4-fluorophenylacetate.

1. temperatureis refluxed for 7 hours with a Dean-Stark separator
2. washThe solution is washed with a 10% aqueous solution of sodium carbonate (2×500 ml) and with water (2×500 ml)
3. dry with materialAfter drying over magnesium sulphate
4. customthe solvent and the excess 2-propanol are evaporated in vacuo
5. distillationThe residue is distilled (51°-53°/3·10-2Torr)