反应详情

A solution of morpholine (12.67 g) and 2-methoxymethyl-4-chloropyrimidine (7.69 g) in tetrahydrofuran (100 ml) was heated under reflux for 1 hour. On cooling, the mixture was treated with water (100 ml), the pH adjusted to 8 (conc HCl) and extracted with chloroform. After drying (K2CO3) the extracts were stripped, and the residue purified by chromatography (silica gel, CHCl3 /methanol) to give 2-methoxymethyl-4-morpholinopyrimidine (5.4 g) as an oil.

1. temperatureunder reflux for 1 hour
2. temperatureOn cooling
3. extractionextracted with chloroform
4. dry with materialAfter drying (K2CO3) the extracts
5. customthe residue purified by chromatography (silica gel, CHCl3 /methanol)