Pyruvic Acid → HCID 70377797, compound

HRID 620232Notes

Reaction equation

HRID 620232 reaction equation
C([NH:11][C@H:12]([C:16]([N:18]([CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[CH2:19][C:20]([OH:22])=[O:21])=[O:17])[CH:13]([CH3:15])[CH3:14])(OCC1C=CC=CC=1)=O.[C:30]([OH:35])(=[O:34])[C:31]([CH3:33])=[O:32]>C(O)C.[Pd]>[C:30]([OH:35])(=[O:34])[C:31]([CH3:33])=[O:32].[C:30]([CH:31]([NH:11][C@H:12]([C:16]([N:18]([CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[CH2:19][C:20]([OH:22])=[O:21])=[O:17])[CH:13]([CH3:15])[CH3:14])[CH3:33])([OH:35])=[O:34]

Participants

5

Reactant 2

HCID 1060Pyruvic AcidHCID 18631782HCID 18631782, compound

Product 1

HCID 70377797HCID 70377797, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a solution of N-carbobenzoxy-L-valyl-N-benzyl glycine (17.2 g, 44.6 mmol) and pyruvic acid (19.6 g, 0.223 mol) in 400 ml absolute ethanol was added 10% palladium on carbon (1.5 g). The mixture was hydrogenated at 50 psi for 4 hours. Filtration and concentration in vacuo provided an oily product which was purified as in example 7D.

Workup

  1. filtrationFiltration and concentration in vacuo
  2. customprovided an oily product which
  3. customwas purified as in example 7D

Sources & evidence

ORD record
ord-274a43f332d4470cac594f8797b20b92
Source dataset
uspto-grants-1989_04
Patent number
US04820729

Reaction notes

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