反应详情

A solution of [4-(2-Ethyl-imidazo[4,5-c]quinolin-1-yl)-butyl]carbamic acid tert-butyl ester of formula 5 obtained in step V in trifluroacetic acid was stirred at 40° C. for 4 hrs. Reaction mixture was then poured on ice-water mixture and extracted with chloroform. Organic layer was dried over sodium sulphate and concentrated under deduced pressure to afford 4-(2-ethyl-1H-imidazo[4,5-c]quinolin-1-yl) butan-1-amine of formula 6.

1. customReaction mixture
2. additionwas then poured on ice-water mixture
3. extractionextracted with chloroform
4. dry with materialOrganic layer was dried over sodium sulphate
5. concentrationconcentrated under deduced pressure