HCID 66900711, compound → HCID 44241236, compound

HRID 62032Notes

Reaction equation

HRID 62032 reaction equation
C(OC(=O)[N:7]([CH2:14][CH2:15][CH2:16][CH2:17][N:18]1[C:30]2[C:29]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[N:23]=[C:22]([NH2:31])[C:21]=2[N:20]=[C:19]1[CH2:32][CH3:33])[CH:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1)(C)(C)C>FC(F)(F)C(O)=O>[CH2:32]([C:19]1[N:18]([CH2:17][CH2:16][CH2:15][CH2:14][NH:7][CH:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)[C:30]2[C:29]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[N:23]=[C:22]([NH2:31])[C:21]=2[N:20]=1)[CH3:33]

Participants

3

Reactant 1

HCID 66900711HCID 66900711, compound

Product 1

HCID 44241236HCID 44241236, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of tert-butyl[4-(4-amino-2-ethyl-1H-imidazo[4,5-c]quinolin-1-yl)butyl]tetrahydro-2H-pyran-4-ylcarbamate in trifluroacetic acid was stirred at 40° C. for 4 hrs. Reaction mixture was then poured on ice-water mixture and extracted with chloroform. Organic layer was dried over sodium sulphate and concentrated under deduced pressure to afford the title compound.

Workup

  1. customReaction mixture
  2. additionwas then poured on ice-water mixture
  3. extractionextracted with chloroform
  4. dry with materialOrganic layer was dried over sodium sulphate
  5. concentrationconcentrated under deduced pressure

Sources & evidence

ORD record
ord-49367b0612614214825570693c4463a9
Source dataset
uspto-grants-2016_09
Patent number
US09446040B2

Reaction notes

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