Triethylamine → HCID 14208280, compound

HRID 620591Notes

Reaction equation

HRID 620591 reaction equation
[NH2:1][C@H:2]1[N:8]=[C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:6]2[CH:15]=[CH:16][CH:17]=[CH:18][C:5]=2[N:4]([CH3:19])[C:3]1=[O:20].[C:21](Cl)(=[O:25])[CH:22]([CH3:24])[CH3:23].C(N(CC)CC)C>C(Cl)Cl>[CH3:19][N:4]1[C:5]2[CH:18]=[CH:17][CH:16]=[CH:15][C:6]=2[C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[N:8][C@H:2]([NH:1][C:21](=[O:25])[CH:22]([CH3:24])[CH3:23])[C:3]1=[O:20]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 62325Isobutyryl chlorideHCID 7216755HCID 7216755, compound

Product 1

HCID 14208280HCID 14208280, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Equimolar amounts of 3(S)-amino-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one, isobutyryl chloride, and triethylamine were mixed in CH2Cl2 at room temperature and stirred 10 minutes. Flash chromatography of the reaction solution on silica gel (10% Et2O in CH2Cl2) provided the title compound as a white foam upon removal of the solvent: m.p. 87°-107° C.

Sources & evidence

ORD record
ord-1a2d27fd40944bc89eefff61da98d686
Source dataset
uspto-grants-1989_04
Patent number
US04820834

Reaction notes

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