Hydrochloric Acid → HCID 20063239, compound

HRID 620607Notes

Reaction equation

HRID 620607 reaction equation
CC(OC(=O)[NH:7][CH:8]([C:13]([N:15]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH:17]([CH2:24][CH:25]2[N:31]=[C:30]([C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)[C:29]3[CH:38]=[CH:39][CH:40]=[CH:41][C:28]=3[NH:27][C:26]2=[O:42])[CH2:16]1)=[O:14])[CH2:9][CH:10]([CH3:12])[CH3:11])(C)C.[ClH:44]>C(OCC)(=O)C>[ClH:44].[NH2:7][CH:8]([CH2:9][CH:10]([CH3:12])[CH3:11])[C:13]([N:15]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH:17]([CH2:24][CH:25]2[N:31]=[C:30]([C:32]3[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=3)[C:29]3[CH:38]=[CH:39][CH:40]=[CH:41][C:28]=3[NH:27][C:26]2=[O:42])[CH2:16]1)=[O:14]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21246577HCID 21246577, compound

Product 1

HCID 20063239HCID 20063239, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The procedure of Example 2 was carried out in which (1-[(3-[(2,3-dihydro-2-oxo-5-phenyl-1,4-benzodiazepin-3-yl)methyl]-2,3-dihydro-1H-indol-1-yl) carbonyl]-3-methylbutyl]-carbamic acid-1,1-dimethylethyl ester was reacted with excess HCl gas in ethyl acetate at 0° C. to give the title compound as a foam.

Sources & evidence

ORD record
ord-01463027e80e4c96aed9d6c3c7b223af
Source dataset
uspto-grants-1989_04
Patent number
US04820834

Reaction notes

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