Acetic Anhydride → HCID 14770490, compound

HRID 620659Notes

Reaction equation

HRID 620659 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[S:9]([NH:12][C:13]1[N:23]=[C:16]2[N:17]=[C:18]([CH3:22])[CH:19]=[C:20]([CH3:21])[N:15]2[N:14]=1)(=[O:11])=[O:10].[C:24](OC(=O)C)(=[O:26])[CH3:25].C(N(CC)CC)C>CN(C=O)C>[C:24]([N:12]([C:13]1[N:23]=[C:16]2[N:17]=[C:18]([CH3:22])[CH:19]=[C:20]([CH3:21])[N:15]2[N:14]=1)[S:9]([C:3]1[C:4]([Cl:8])=[CH:5][CH:6]=[CH:7][C:2]=1[Cl:1])(=[O:10])=[O:11])(=[O:26])[CH3:25]

Participants

5

Reactant 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 13772900HCID 13772900, compound

Product 1

HCID 14770490HCID 14770490, compoundYield 39%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 0.50 g (1.3 mmol) of 2,6-dichloro-N-(5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidin-2-yl)benzenesulfonamide, 2.12 ml (22.5 mmol) of acetic anhydride and 0.18 ml (1.3 mmol) of triethylamine in 4 ml of DMF was heated at 85° C. for 3 days. After cooling to room temperature, the product separated from solution and was collected by filtration and dried in vacuo to yield 0.20 g (39 percent) of the desired product as a solid, mp 219°-222° C. The product was characterized by IR and NMR spectroscopy.

Workup

  1. customthe product separated from solution
  2. filtrationwas collected by filtration
  3. customdried in vacuo

Sources & evidence

ORD record
ord-e9029fcfeebd46f0a4dd67ac3fdfc742
Source dataset
uspto-grants-1989_04
Patent number
US04822404

Reaction notes

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