Acetic Anhydride → HCID 178491907, compound

HRID 620842Notes

Reaction equation

HRID 620842 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([Cl:9])[C:6]([NH2:10])=[CH:5][C:4]=1[C:11]1[NH:12][C:13]([C:17]2[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=2)=[C:14]([CH3:16])[N:15]=1.[C:23](OC(=O)C)(=[O:25])[CH3:24]>C(OCC)(=O)C.O1CCCC1>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([Cl:9])[C:6]([NH:10][C:23](=[O:25])[CH3:24])=[CH:5][C:4]=1[C:11]1[NH:12][C:13]([C:17]2[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=2)=[C:14]([CH3:16])[N:15]=1

Participants

5

Reactant 2

HCID 7918Acetic AnhydrideHCID 178491906HCID 178491906, compound

Product 1

HCID 178491907HCID 178491907, compound

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 8857Ethyl AcetateSolvent

Procedure

A solution of 2-(2-methoxy-4-chloro-5-aminophenyl)-4-methyl-5-(3-pyridyl)imidazole (1.0 g) and acetic anhydride (2 ml) in a mixture of ethyl acetate (20 ml) and tetrahydrofuran (10 ml) was refluxed for 2 hours. The reaction mixture was cooled with ice-water and the crystalline residue was collected by filtration to give 2-(2-methoxy-4-chloro-5-acetamidophenyl)-4-methyl-5-(3-pyridyl)imidazole (0.7 g).

Workup

  1. temperaturewas refluxed for 2 hours
  2. filtrationthe crystalline residue was collected by filtration

Sources & evidence

ORD record
ord-ac617afb86694bb2a2645ff5fde64af6
Source dataset
uspto-grants-1989_04
Patent number
US04822805

Reaction notes

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