反应详情

Prepared from VII and 2,4-difluoroaniline. Flash chromatography eluent (DCM-EtOAc, 7:3). Yield: 68%; yellow solid; mp>260° C.; IR (KBr) νmax/cm−1 2228, 1645, 1611, 1583, 1557, 1488, 1460, 1378, 1357, 1311, 1276, 1260, 1172, 1138, 1091, 962, 854, 831, 818; 19F NMR (282 MHz, DMSO-d6) δ −117.6, −118.7; 1H NMR (300 MHz, DMSO-d6) δ 8.54 (d, 1H, J=9.0 Hz), 8.22 (s, 1H), 7.78 (d, 1H, J=9.0 Hz), 7.35-7.24 (m, 2H), 7.06 (t, 1H, J=7.8 Hz); HRMS calcd for C16H8N5SF2 (M+H+): 340.0468, found 340.0458.