反应详情

To a suspension of 49.8 g of 2,4-diamino-6-cyclopropylamino-1,3,5-triazine and 45.5 g of triethylamine in 1200 ml of tetrahydrofuran are slowly added dropwise, at about 60° C. (in about 6 hours), 31.7 g of acetic acid anhydride dissolved in 100 ml of tetrahydrofuran. The reaction mixture is subsequently refluxed for 18 hours, filtered hot and then concentrated by evaporation until crystallisation commences. After the addition of about 300 ml of diethyl ether, the product if filtered off as white crystalline powder. It has a melting point of 190°-195° C.

1. temperatureThe reaction mixture is subsequently refluxed for 18 hours
2. filtrationfiltered hot
3. concentrationconcentrated by evaporation until crystallisation commences
4. additionAfter the addition of about 300 ml of diethyl ether
5. filtrationthe product if filtered off as white crystalline powder