Ammonium Hydroxide → SK&F 103829

HRID 621457Notes

Reaction equation

HRID 621457 reaction equation
Br.[OH:2][C:3]1[C:4]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:5][C:6]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8][C:7]=2[CH:13]=1.[OH-].[NH4+]>>[OH:2][C:3]1[C:4]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:5][C:6]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8][C:7]=2[CH:13]=1

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 212428778-hydroxy-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide

Product 1

HCID 130981SK&F 103829

Procedure

8-Hydroxy-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide was treated with ammonium hydroxide. The resulting mixture was filtered to give 8-hydroxy-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine, m.p. 241°-242°. This was treated with methanesulfonic acid to give the methanesulfonate, m.p. 267°-269°.

Workup

  1. filtrationThe resulting mixture was filtered

Sources & evidence

ORD record
ord-e4234953389346b58c9e06c870aec087
Source dataset
uspto-grants-1989_04
Patent number
US04824839

Reaction notes

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