Hydrochloric Acid → HCID 21242901, compound

HRID 621459Notes

Reaction equation

HRID 621459 reaction equation
C(N1CCC2C=CC(S([Cl:18])(=O)=O)=CC=2CC1)(=O)C.C(N1CCC2C=CC(SC)=CC=2CC1)(=O)C.C([N:38]1[CH2:44][CH2:43][C:42]2[CH:45]=[CH:46][C:47]([S:49]([CH3:51])=[O:50])=[CH:48][C:41]=2[CH2:40][CH2:39]1)(=O)C.Cl>>[ClH:18].[CH3:51][S:49]([C:47]1[CH:46]=[CH:45][C:42]2[CH2:43][CH2:44][NH:38][CH2:39][CH2:40][C:41]=2[CH:48]=1)=[O:50]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 113467373-acetyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7-sulfonyl chlorideHCID 21242874HCID 21242874, compoundHCID 21242882HCID 21242882, compound

Product 1

HCID 21242901HCID 21242901, compound

Procedure

Following the procedure of Examples 4 and 5, 3-acetyl-7-chlorosulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine is converted to 3-acetyl-7-methylthio-2,3,4,5-tetrahydro-1H-3-benzazepine and then to 3-acetyl-7-methylsulfinyl-2,3,4,5-tetrahydro-1H-3-benzazepine which is hydrolyzed with dilute hydrochloric acid to give 7-methylsulfinyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride.

Sources & evidence

ORD record
ord-20a6adb0b0ed4db3a4ef1b5258abd4fd
Source dataset
uspto-grants-1989_04
Patent number
US04824839

Reaction notes

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