反应详情

To a solution of 7.05 g (0.04 mol) of 3-(5-methyl-1,3,4-oxadiazol-2-yl)benzenamine and 10 ml of triethylamine in 300 ml of dichloromethane is added 11 g of 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoyl chloride (U.S. Pat. No. 4,285,951). The mixture is worked up, the crude product slurried in ethyl acetate and filtered through silica gel. The solvent is evaporated to give 1.2 g of 5-(2,5-dimethylphenoxy)-2,2-dimethyl-N-[3-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]pentanamide after recrystallization from 2-propanol; mp 90°-92° C.

1. filtrationfiltered through silica gel
2. customThe solvent is evaporated