Hydrochloric Acid → HCID 178448666, compound

HRID 621497Notes

Reaction equation

HRID 621497 reaction equation
[CH2:1]([N:5]1[C:10](=[O:11])[C:9]2[C:12]([NH:15][CH3:16])=[N:13][NH:14][C:8]=2[N:7]([CH2:17][C:18]2[CH:23]=[CH:22][C:21]([N+:24]([O-])=O)=[CH:20][CH:19]=2)[C:6]1=[O:27])[CH2:2][CH2:3][CH3:4].[ClH:28]>C(O)C>[ClH:28].[NH2:24][C:21]1[CH:20]=[CH:19][C:18]([CH2:17][N:7]2[C:8]3[NH:14][N:13]=[C:12]([NH:15][CH3:16])[C:9]=3[C:10](=[O:11])[N:5]([CH2:1][CH2:2][CH2:3][CH3:4])[C:6]2=[O:27])=[CH:23][CH:22]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178448667HCID 178448667, compound

Product 1

HCID 178448666HCID 178448666, compoundYield 46%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

To a suspension of 5-butyl-3-methylamino-7-(4-nitrobenzyl)pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione (1 g, 2.6 mM) in concentrated hydrochloric acid (5 ml) and ethanol (2.5 ml) was added dropwise a solution of stannous chloride (3.75 g) in ethanol (5 ml) at room temperature with stirring. The mixture was stirred at room temperature for 24 hours and concentrated to dryness. The residue was crystallized from hot water to give yellow crystals (0.42 g, 46%), m.p. >310° C.

Workup

  1. stirringThe mixture was stirred at room temperature for 24 hours
  2. concentrationconcentrated to dryness
  3. customThe residue was crystallized from hot water

Sources & evidence

ORD record
ord-6ca1c29dd473400687a52ade9d13687f
Source dataset
uspto-grants-1989_04
Patent number
US04824848

Reaction notes

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