反应详情

To an ice-cold mixture of 4-hydroxy-2-oxo-1-pyrrolidineacetic acid (1 g) and glycinamide (700 mg) in dimethylformamide (20 ml), dicyclohexylcarbodiimide (1.3 g) was added at once. Stirring was continued for 5 hours at room temperature, then the solvent was removed under vacuum. The residue was suspended in water (20 ml) and stirred for 30 minutes at room temperature. The insoluble material was filtered off and the filtrate evaporated to dryness. The residue was triturated with 2-propanol to yield the title compound (700 mg).

1. additionwas added at once
2. customthe solvent was removed under vacuum
3. stirringstirred for 30 minutes at room temperature
4. filtrationThe insoluble material was filtered off
5. customthe filtrate evaporated to dryness
6. customThe residue was triturated with 2-propanol