1,1-Dimethylhydrazine → HCID 14407600, compound

HRID 621770Notes

Reaction equation

HRID 621770 reaction equation
[C:1]([OH:16])(=O)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14].C(C1NC=CN=1)(C1NC=CN=1)=O.[CH3:29][N:30]([NH2:32])[CH3:31]>O1CCCC1>[CH3:29][N:30]([CH3:31])[NH:32][C:1](=[O:16])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14]

Participants

5

Reactant 3

HCID 59761,1-DimethylhydrazineHCID 11005Myristic AcidHCID 5250894Bis-(1H-imidazol-2-YL)-methanone

Product 1

HCID 14407600HCID 14407600, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

690 mg (3 meq) of myristic acid and 486 mg (3 meq) of carbonyl diimidazole are reacted in a minimum volume of tetrahydrofuran at room temperature for 1 hour. Unsym-dimethylhydrazine (0.23 ml, 3 meq) is added and reacted overnight at room temperature. The reaction mixture is evaporated under reduced pressure, dried in vacuo and purified on a silica gel column using CH2Cl2 :CH3OH (5:1). The fractions having R6 0.76 on TLC S.G. CH2Cl2 :CH3OH (5:1) chlorine-peptide spray are combined, evaporated under reduced pressure and dried in vacuo to yield 185 mg of title compound having a m.p. of 63.5°-64.5° C.

Workup

  1. customreacted overnight at room temperature
  2. customThe reaction mixture is evaporated under reduced pressure
  3. customdried in vacuo
  4. custompurified on a silica gel column
  5. customevaporated under reduced pressure
  6. customdried in vacuo

Sources & evidence

ORD record
ord-bf1bbb8a91f34f5ca38a99f372886ebd
Source dataset
uspto-grants-1989_04
Patent number
US04824996

Reaction notes

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