Myristic Acid → HCID 9972710, compound

HRID 621771Notes

Reaction equation

HRID 621771 reaction equation
[C:1]([OH:16])(=O)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14].C(C1NC=CN=1)(C1NC=CN=1)=O.[CH3:29][N:30]1[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]1>O1CCCC1>[CH3:29][N:30]1[CH2:35][CH2:34][N:33]([C:1](=[O:16])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14])[CH2:32][CH2:31]1

Participants

5

Reactant 3

HCID 11005Myristic AcidHCID 531671-MethylpiperazineHCID 5250894Bis-(1H-imidazol-2-YL)-methanone

Product 1

HCID 9972710HCID 9972710, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

680 mg (3 meq) of myristic acid and 486 mg (3 meq) of carbonyl diimidazole are reacted in a minimum volume of tetrahydrofuran at ambient temperature for 1.5 hours. 1-Methyl-piperazine (0.33 ml, 3 meq) is added and reacted overnight at ambient temperature. The reaction mixture is evaporated under reduced pressure, dried in vacuo and purified on a column of silica gel in the system CH2Cl2 :CH3OH (5:1). The fractions having Rf 0.80 on TLC silica gel CH2Cl2 :CH3OH (5:1)-iodine are combined, evaporated under reduced pressure (<30°) and dried in vacuo to yield 85 mg of title compound.

Workup

  1. customreacted overnight at ambient temperature
  2. customThe reaction mixture is evaporated under reduced pressure
  3. customdried in vacuo
  4. custompurified on a column of silica gel in the system CH2Cl2 :CH3OH (5:1)
  5. customevaporated under reduced pressure (<30°)
  6. customdried in vacuo

Sources & evidence

ORD record
ord-e3d4841801894ca28bf64a212cb8be54
Source dataset
uspto-grants-1989_04
Patent number
US04824996

Reaction notes

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