反应详情

Prepared by the method described in Example 1 from ethyl α-isopropylacetoacetate (prepared by the procedure of Manuel and Hagen, Org. Syn., 7, 248 (1951)) (12 g, 70 mmoles), methyl thioglycolate (15.7 g, 140 mmoles) and sodium (3.2 g, 139 mmoles). The product is extracted with CH2Cl2 twice. The combined extracts are washed with aqueous NaCl twice, dried over MgSO4 and stripped of solvent under reduced pressure. Distillation of the residue gave the product (3.3 g); bp 68°-71° C. (0.3 mmHg).

1. customPrepared by the method
2. customprepared by the procedure of Manuel and Hagen, Org
3. extractionThe product is extracted with CH2Cl2 twice
4. washThe combined extracts are washed with aqueous NaCl twice
5. dry with materialdried over MgSO4
6. distillationDistillation of the residue