1,1'-Carbonyldiimidazole → HCID 178458115, compound

HRID 621809Notes

Reaction equation

HRID 621809 reaction equation
[Br:1][C:2]1[C:3]([O:12][CH:13]([CH3:15])[CH3:14])=[C:4]([C:9](O)=[O:10])[N:5]([CH3:8])[C:6]=1[Br:7].C(N1C=CN=C1)(N1C=CN=C1)=O.[NH2:28][C:29]1[NH:33][N:32]=[N:31][N:30]=1>>[Br:1][C:2]1[C:3]([O:12][CH:13]([CH3:15])[CH3:14])=[C:4]([C:9]([NH:28][C:29]2[NH:33][N:32]=[N:31][N:30]=2)=[O:10])[N:5]([CH3:8])[C:6]=1[Br:7]

Participants

4

Reactant 3

HCID 682631,1'-CarbonyldiimidazoleHCID 14154271HCID 14154271, compoundHCID 178509299HCID 178509299, compound

Product 1

HCID 178458115HCID 178458115, compoundYield 51.5%

Procedure

Prepared by the method described in Example 115 from 4,5-dibromo-3-(1-methylethoxy)-1-methyl-1H-pyrrole-2-carboxylic acid (3.5 g, 0.01 moles), 1,1'-carbonyldiimidazole (1.7 g, 0.01 moles), and 5-aminotetrazole (0.87 g, 0.01 moles). Recrystallization from ethyl acetate gave the product (2.1 g); mp 218°-220° C. (dec).

Workup

  1. customPrepared by the method
  2. customRecrystallization from ethyl acetate

Sources & evidence

ORD record
ord-3bee8e1034b34d3a9c9a3ec7e26c604e
Source dataset
uspto-grants-1989_04
Patent number
US04824958

Reaction notes

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