反应详情

A 1 liter reactor is charged with 300 ml of methyl isobutyl ketone, 73.1 g of 3-diethylaminophenol and 153.3 g of ground potassium carbonate and the mixture is stirred for 30 minutes. Then 72.7 g of ethyl bromide are introduced into the autoclave, which is then closed and heated for 3 hours to 115°-120° C. The temperature is then kept for a further 5 hours at 140°-142° C. (pressure: 5 bar). The contents of the autoclave are cooled to c. 25° C. and potassium bromide is removed by filtration. After washing with a small amount of methyl isobutyl ketone, the combined filtrates are concentrated by evaporation, to give 75.6 g (91.1% yield) of 3-diethylaminophenetol with a titre of 96.9%.

1. customis then closed
2. temperatureheated for 3 hours to 115°-120° C
3. waitThe temperature is then kept for a further 5 hours at 140°-142° C.
4. temperatureThe contents of the autoclave are cooled to c
5. custom25° C. and potassium bromide is removed by filtration
6. washAfter washing with a small amount of methyl isobutyl ketone
7. concentrationthe combined filtrates are concentrated by evaporation