反应详情

A 1 liter reactor is charged with 150 ml of methyl isobutyl ketone, 73.1 g of 3-diethylaminophenol and 153.3 g of ground potassium carbonate. The mixture is stirred for 30 minutes, then 72.7 g of ethyl bromide are added and the autoclave is closed. The reaction mixture is heated first for 3 hours to 115°-129° C. and then for a further 5 hours at 140°-142° C. (pressure: 4 bar). After cooling to c. 25° C. and addition of water, the product is isolated with the organic phase, which is washed with water and concentrated by evaporation, to give 80.67 g (97.2% yield) of 3-diethylaminophenetol with a titre of 94.8%.

1. customthe autoclave is closed
2. temperatureThe reaction mixture is heated first for 3 hours to 115°-129° C.
3. waitfor a further 5 hours at 140°-142° C. (pressure: 4 bar)
4. temperatureAfter cooling to c
5. customthe product is isolated with the organic phase, which
6. washis washed with water
7. concentrationconcentrated by evaporation