Benzyl Alcohol → HCID 22152760, compound

HRID 621832Notes

Reaction equation

HRID 621832 reaction equation
[H-].[Na+].[CH2:3]([OH:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[O:11]1[CH:13]([CH2:14][O:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([F:25])([F:24])[F:23])[CH:17]=2)[CH2:12]1>C1COCC1>[C:4]1([CH2:3][O:10][CH2:12][CH:13]([OH:11])[CH2:14][O:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([F:23])([F:24])[F:25])[CH:17]=2)[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

5

Reactant 3

HCID 244Benzyl AlcoholHCID 24758Sodium hydrideHCID 328877585-45-5

Product 1

HCID 22152760HCID 22152760, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Sodium hydride (80% dispersion in oil, 0.045 g) was added to a mixture of benzyl alcohol (4 ml) and THF (3 ml) and warmed gently until effervescence ceased. To the cooled solution was added 1,2-epoxy-3-[3-(trifluoromethyl)phenoxy]propane (2.12 g). After stirring for 3 h the mixture was poured into ER (50 ml) and washed with brine. The dried extracts were evaporated and the residue distilled (b.p. 140°-144°/0.03 mm) to yield the title compound as an oil (2.25 g). I.r. (Neat) 3420 cm-1

Workup

  1. temperaturewarmed gently until effervescence
  2. additionwas poured into ER (50 ml)
  3. washwashed with brine
  4. customThe dried extracts were evaporated
  5. distillationthe residue distilled (b.p. 140°-144°/0.03 mm)

Sources & evidence

ORD record
ord-287433d3afec4ce991ec6b6c871b83c9
Source dataset
uspto-grants-1989_04
Patent number
US04824993

Reaction notes

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