反应详情

Under nitrogen bubbling, a mixture of 2-(3,4-dichlorophenyl)-3H-imidazo[4,5-b]pyridine-3-acetic acid (3.5 g, 0.011 mole) and 1,1'-carbonyldiimidazole (1.95 g, 0.011 mole) in 150 ml of tetrahydrofuran was stirred at room temperature for 2 hrs, then heated at 60°-65° C. for 2 hrs. N,N-Dimethylaminoethylamine (1.06 g, 0.012 mole) was added and the reaction mixture was allowed to stir at room temperature. The reaction mixture was filtered and the filtrate was evaporated to dryness, then placed under high vacuum overnight. The solid was treated with ice water, collected by filtration, washed with water, and dried under high vacuum at 50° overnight. The solid was dissolved in acetone and acidified with ethanolic hydrogen chloride. The crystalline precipitate was collected by filtration, washed with cold acetone, and dried under high vacuum to give 3.61 g. The solid was dissolved in 1.2 liters of acetone and concentrated to 600 ml to initiate crystallization. The solid was collected by filtration, washed with acetone, and dried under high vacuum overnight at 50° C. to give 1.9 g of title compound, mp 120°-122° C.

1. temperatureheated at 60°-65° C. for 2 hrs
2. stirringto stir at room temperature
3. filtrationThe reaction mixture was filtered
4. customthe filtrate was evaporated to dryness
5. customplaced under high vacuum overnight
6. additionThe solid was treated with ice water
7. filtrationcollected by filtration
8. washwashed with water
9. customdried under high vacuum at 50° overnight
10. dissolutionThe solid was dissolved in acetone
11. filtrationThe crystalline precipitate was collected by filtration
12. washwashed with cold acetone
13. customdried under high vacuum
14. customto give 3.61 g
15. concentrationconcentrated to 600 ml
16. customcrystallization
17. filtrationThe solid was collected by filtration
18. washwashed with acetone
19. customdried under high vacuum overnight at 50° C.