反应详情

A solution of 4.0 g of α, α-bis(4-chlorophenyl)-5-pyrimidinemethanol in 25 ml of methanesulfonic acid was stirred under a nitrogen atmosphere for 18 hours. The solution was poured into a sodium bicarbonate solution and extracted with ethyl acetate. The organic extract was washed with a saturated sodium chloride solution, dried over magnesium sulfate, and concentrated in vacuo. Recrystallization from ethyl acetate/isooctane provided 1.95 g of the desired title product, m.p. 158°-163° C.

1. extractionextracted with ethyl acetate
2. extractionThe organic extract
3. washwas washed with a saturated sodium chloride solution
4. dry with materialdried over magnesium sulfate
5. concentrationconcentrated in vacuo
6. customRecrystallization from ethyl acetate/isooctane