反应详情

温度

0 °C

A 1-liter three-necked round bottom flask was equipped with a mechanical stirrer, an addition funnel, Dry Ice/acetone reflux condenser and a means for providing nitrogen atmosphere. To the flask were added 67 g (0.4 mole) of carbazole, 11 g (0.44 mole) of sodium hydride and 0.5 liter of dry tetrahydrofuran. After stirring vigorously at 0° C. for about 2.5 hours, 18 g (0.4 mole) of ethylene oxide was added dropwise to the reaction mixture over a period of 1 hour at 0° C. After the addition, stirring was continued for additional 5 hours and the tetrahydrofuran was evaporated. The residue was fully washed with water and then recrystallized from ether to give 80 g of N-(2-hydroxyethyl)-carbazole.

1. customA 1-liter three-necked round bottom flask was equipped with a mechanical stirrer, an addition funnel
2. customfor providing nitrogen atmosphere
3. additionAfter the addition
4. stirringstirring
5. waitwas continued for additional 5 hours
6. customthe tetrahydrofuran was evaporated
7. washThe residue was fully washed with water
8. customrecrystallized from ether