反应详情

A mixture of 44 parts of α-phenyl-2-pyridinemethanamine, 27 parts of methyl chloroacetate, 30 parts of N,N-diethylethanamine and 270 parts of N,N-dimethylformamide was stirred overnight at room temperature. The reaction mixture was poured into 1000 parts of water. The product was extracted with 1,1'-oxybisethane. The extract was washed three times with water, dried, filtered and evaporated, yielding 37 parts (62.8%) of methyl N-[phenyl(2-pyridinyl)methyl]glycine as a residue.

1. extractionThe product was extracted with 1,1'-oxybisethane
2. washThe extract was washed three times with water
3. customdried
4. filtrationfiltered
5. customevaporated