Oxalyl chloride → HCID 14235017, compound

HRID 622381Notes

Reaction equation

HRID 622381 reaction equation
[CH3:1][N:2]([CH3:16])[C:3]1[C:11]([F:12])=[C:10]([F:13])[C:9]([F:14])=[C:8]([F:15])[C:4]=1[C:5](O)=[O:6].C(Cl)(=O)C([Cl:20])=O>CN(C=O)C.ClCCl>[CH3:1][N:2]([CH3:16])[C:3]1[C:11]([F:12])=[C:10]([F:13])[C:9]([F:14])=[C:8]([F:15])[C:4]=1[C:5]([Cl:20])=[O:6]

Participants

5

Reactant 2

HCID 65578Oxalyl chlorideHCID 14235016HCID 14235016, compound

Product 1

HCID 14235017HCID 14235017, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 6344DichloromethaneSolvent

Procedure

To a suspension of 4.22 g (17.8 mmol) of 2-(dimethylamino)-3,4,5,6-tetrafluoro-benzoic acid and 85 ml of dichloromethane, added 1.7 ml (19.5 mmol) of oxalyl chloride. After the bubbling subsided, five drops of DMF was added and the solution was stirred at room temperature for 21 hours. The solution was evaporated to 4.8 g of an oil which was used in the next step without purification.

Workup

  1. customThe solution was evaporated to 4.8 g of an oil which
  2. customwas used in the next step without purification

Sources & evidence

ORD record
ord-a4a8cb8b978b4cc0ade97a9330036f71
Source dataset
uspto-grants-1988_09
Patent number
US04771055

Reaction notes

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