Hydrochloric Acid → 3-Methoxyiminopyrrolidine hydrochloride

HRID 622449Notes

Reaction equation

HRID 622449 reaction equation
[ClH:1].C(OC([N:9]1[CH2:13][CH2:12][C:11](=[N:14][O:15][CH3:16])[CH2:10]1)=O)(C)(C)C.CCOCC>C(OCC)(=O)C>[ClH:1].[CH3:16][O:15][N:14]=[C:11]1[CH2:12][CH2:13][NH:9][CH2:10]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 536718421-(t-Butoxycarbonyl)-3-methoxyiminopyrrolidine

Product 1

HCID 867424283-Methoxyiminopyrrolidine hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
40 °C

Procedure

7 ml of a 3M hydrogen chloride solution in ethyl acetate was added to 2.3 g of ice-cooled 1-(t-butoxycarbonyl)-3-methoxyiminopyrrolidine, and the mixture was stirred at about 40° C. for one hour. After completion of the reaction, the solvent was stripped off from the reaction mixture and ether was added to the residue. The crystals which formed were collected by filtration and washed with ether, giving 1.5 g of the title compound.

Workup

  1. customAfter completion of the reaction
  2. additionwas added to the residue
  3. customThe crystals which formed
  4. filtrationwere collected by filtration
  5. washwashed with ether

Sources & evidence

ORD record
ord-717408610b5640e58a55825510da26e4
Source dataset
uspto-grants-1988_09
Patent number
US04771046

Reaction notes

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