Pyridine → HCID 135617167, compound

HRID 622672Notes

Reaction equation

HRID 622672 reaction equation
[NH2:1][C:2]1[N:3]([CH2:13][C:14]2[S:15][CH:16]=[CH:17][CH:18]=2)[C:4]2[N:5]=[C:6]([NH2:12])[NH:7][C:8](=[O:11])[C:9]=2[N:10]=1.CN([CH:22]=[O:23])C.N1C=CC=C[CH:25]=1.[C:30](OC(=O)C)(=[O:32])[CH3:31]>CCOCC>[O:11]=[C:8]1[NH:7][C:6]([NH:12][C:30](=[O:32])[CH3:31])=[N:5][C:4]2[N:3]([CH2:13][C:14]3[S:15][CH:16]=[CH:17][CH:18]=3)[C:2]([NH:1][C:22](=[O:23])[CH3:25])=[N:10][C:9]1=2

Participants

6

Reactant 4

HCID 1049PyridineHCID 6228DimethylformamideHCID 7918Acetic AnhydrideHCID 1354009088-Amino-9-(2-thienylmethyl)guanine

Product 1

HCID 135617167HCID 135617167, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A mixture of 8-amino-9-[(2-thienyl)methyl]guanine (0.5 g; 1.88 mmol), DMF (10 ml), pyridine (5 ml), and acetic anhydride (5 ml) was stirred at room temperature for 36 hours. The mixture was diluted with ether (50 ml) and filtered to give analytically pure product, mp 243°-4° C.

Workup

  1. filtrationfiltered
  2. customto give analytically pure product, mp 243°-4° C.

Sources & evidence

ORD record
ord-269cd4eedb054ca7af13eedc302ccae0
Source dataset
uspto-grants-1988_09
Patent number
US04772606

Reaction notes

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