Methylamine → HCID 178482378, compound

HRID 622712Notes

Reaction equation

HRID 622712 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[O:9][C:8]([CH2:10][S:11][CH2:12][CH2:13][CH:14]2[N:18]=[C:17](C(Cl)(Cl)Cl)[O:16][N:15]2[NH2:23])=[CH:7][CH:6]=1)[CH3:3].[CH3:24][NH2:25]>C(O)C>[CH3:1][N:2]([CH2:4][C:5]1[O:9][C:8]([CH2:10][S:11][CH2:12][CH2:13][CH:14]2[N:18]=[C:17]([NH:25][CH3:24])[O:16][N:15]2[NH2:23])=[CH:7][CH:6]=1)[CH3:3]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 70417220HCID 70417220, compound

Product 1

HCID 178482378HCID 178482378, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
50 °C

Procedure

The oxadiazole from Example 16 (3 g, 7.5 mmol) is dissolved in 25 ml of ethanol saturated with methylamine and the solution heated in a sealed tube at 50° C. for 16 hours. The mixture is concentrated to provide 3-[2-[(5-Dimethylaminomethyl-2-furanyl)methylthio]ethyl]-amino-5-methylamino-1,2,4-oxadiazole as an oil.

Workup

  1. concentrationThe mixture is concentrated

Sources & evidence

ORD record
ord-88aedf588e7044ff8f01f9db60d72e11
Source dataset
uspto-grants-1988_09
Patent number
US04772622

Reaction notes

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